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Interaction between a cationic polymethacrylate (Eudragit E100) and anionic drugs.

Daniela A Quinteros1, Verónica Ramirez Rigo, Alvaro F Jimenez Kairuz

  • 1Departamento de Farmacia, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Argentina.

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
|December 7, 2007
PubMed
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This study shows that Eudragit E (EU) forms stable complexes with acidic drugs (AH), enhancing drug solubility and enabling controlled release. The EU-AH system acts as a drug reservoir, delivering medication effectively in simulated biological fluids.

Area of Science:

  • Polymer chemistry
  • Pharmaceutical sciences
  • Materials science

Background:

  • Cationic polymethacrylates like Eudragit E (EU) are used in drug delivery.
  • Understanding drug-polymer interactions is crucial for formulation development.
  • Acidic drugs (AH) often exhibit poor aqueous solubility.

Purpose of the Study:

  • To investigate the complexation of Eudragit E (EU) with acidic drugs (AH).
  • To characterize the resulting stable solid ionic complexes.
  • To evaluate the drug solubility enhancement and release characteristics of these complexes.

Main Methods:

  • Preparation of EU-AH50 and EU-AH50Cl50 complexes.
  • Characterization using infrared spectroscopy and X-ray powder diffraction.

Related Experiment Videos

  • Solubility and drug release studies using bicompartimental Franz cells.

    • Main Results:

    • Stable solid ionic complexes were formed, enhancing the apparent solubility of acidic drugs.
    • EU-AH50Cl50 complexes formed clear, optically isotropic aqueous dispersions.
    • High counterion condensation (up to 97.9%) was observed for diclofenac complex.
    • Drug delivery was slow in water but increased with NaCl concentration due to ionic exchange.

    Conclusions:

    • The Eudragit E-acidic drug system effectively increases drug solubility.
    • The developed complexes act as drug reservoirs with tunable release profiles.
    • Ionic exchange mechanisms play a significant role in drug delivery from these systems.