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Updated: Jul 9, 2026
An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
Published on: December 10, 2013
[Respiratory syncytial virus in hospitalized children. A 3-year study]
Marie-Joëlle El-Hajje1, Florence Moulin, Nathalie de Suremain
1Services de pédiatrie et d'accueil des urgences, Faculté de médecine Paris V, Hôpital Saint-Vincent-de-Paul-Cochin, F-75014 Paris, France.
Insights
Respiratory syncytial virus (RSV) was the most common cause of pediatric respiratory hospitalizations in Paris between 2001-2004. Influenza was more frequent only for isolated fever cases.
Area of Science:
- Pediatric infectious diseases
- Virology
- Epidemiology
Context:
- Hospitalized children in Paris (2001-2004)
- Focus on respiratory viruses
- Common pediatric respiratory illnesses
Purpose:
- Assess prevalence of respiratory syncytial virus (RSV) and other respiratory viruses
- Identify common viral pathogens in pediatric hospitalizations
- Understand viral epidemiology in French children
Summary:
- RSV was the most frequently isolated virus (375/1208 patients)
- 74% of RSV cases were in infants under 6 months with bronchiolitis
- Influenza was more common than RSV only in isolated fever cases
- Adenoviruses and parainfluenza viruses were less frequent
Impact:
- RSV is a significant pathogen in young children
- Highlights regional differences in parainfluenza virus prevalence
- Informs public health strategies and clinical management of pediatric respiratory infections
Objective:
To assess the prevalence of respiratory syncytial virus (RSV) and other important respiratory viruses in children hospitalized in a pediatric hospital in Paris (France) during a 3-year period (2001 to 2004).
Patients And Methods:
The study included all patients aged 8 days to 16 years admitted from the community through emergency department with bronchiolitis, pneumonia, upper respiratory tract infection, asthma or acute isolated fever and who had nasopharyngeal samples taken for viral identification by immunofluorescence (RSV, influenza, para-influenza, and adenoviruses).
Results:
A virus was found in 464 of 1208 patients with samples taken. RSV was identified in 375 patients, 74% of them younger than 6 months and diagnosed with bronchiolitis. RSV was isolated more often than any other virus, overall and for all diagnoses except "isolated fever," for which influenza was more frequent. In patients aged 24 months or older, influenza and RSV were identified at the same frequency. Overall, influenza virus was found in 53 patients, adenoviruses in 24 and para-influenza viruses in 11.
Conclusion:
RSV was the respiratory virus isolated most often, even in older children, during this 3-year study. The relative rarity of hospitalizations due to para-influenza viruses is characteristic of this area, compared with some other countries.
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