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Related Experiment Video

Updated: Jul 9, 2026

Generation and Genetic Manipulation of Human Cervical Organoids

Generation and Genetic Manipulation of Human Cervical Organoids

Published on: March 10, 2026

Cervical cancer prevention--cervical screening: science in evolution.

Mahboobeh Safaeian¹, Diane Solomon, Philip E Castle

¹Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health/DHHS, 6120 Executive Blvd., Rockville, MD 20852, USA. safaeianm@mail.nih.gov

Obstetrics and Gynecology Clinics of North America

|December 7, 2007

Summary

Cervical cancer screening has significantly reduced US incidence and mortality. However, it remains a global burden, especially in low-resource settings, due to limited access to screening and treatment.

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Published on: November 2, 2020

Area of Science:

Oncology
Public Health
Gynecology

Background:

Cervical cancer incidence and mortality have decreased over 70% in the US since the 1950s.
The Papanicolaou test, introduced in the 1940s, is credited with this significant decline.
Globally, cervical cancer is the second most common female malignancy, with 80% of cases in resource-poor countries.

Purpose of the Study:

To describe traditional cervical cancer screening methods.
To explore innovative screening methods for cervical cancer.
To address financial and cultural barriers hindering widespread cervical cancer screening.

Main Methods:

Review of traditional cervical cancer screening techniques.
Exploration of novel approaches for cervical cancer detection.
Analysis of barriers to screening in diverse populations.

Main Results:

The Papanicolaou test has been highly effective in reducing cervical cancer rates in developed nations.
Significant disparities in cervical cancer burden exist globally, linked to screening access.
Innovative methods show potential to overcome barriers to widespread screening.

Conclusions:

While effective in some regions, traditional screening methods face challenges in global implementation.
Addressing financial and cultural barriers is crucial for reducing the worldwide burden of cervical cancer.
Further research into innovative and accessible screening technologies is warranted.