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The Menopausal Transition and Cardiovascular Aging: Implications for Prevention in Midlife
Ziyuan Wang1, Samar R El Khoudary2
1Global Patient Safety Pharmacoepidemiology, Eli Lilly and Company, Indianapolis, IN, USA.
Obstetrics and Gynecology Clinics of North America
|July 27, 2026
Summary
Midlife women face accelerated cardiovascular aging due to lifestyle and risk factors. Early prevention strategies targeting these modifiable factors are crucial for healthy aging.
Area of Science:
- Cardiovascular Health
- Aging Biology
- Women's Health
Background:
- Midlife, particularly the menopause transition, is critical for women's cardiovascular health.
- Cardiovascular aging can accelerate due to unhealthy lifestyles and cardiometabolic risks.
- Factors include hypertension, dyslipidemia, insulin resistance, obesity, inflammation, and environmental exposures.
Purpose of the Study:
- To highlight the complexity of cardiovascular aging during midlife in women.
- To identify modifiable targets for preventive strategies.
- To emphasize the opportunity for early intervention to promote healthy aging.
Main Methods:
- This abstract does not detail specific methods.
- The study focuses on the biological and lifestyle interactions during midlife cardiovascular aging.
- It reviews the interplay of vascular and myocardial remodeling with cellular aging hallmarks.
Main Results:
- Cardiovascular aging dynamics are complex during midlife, influenced by multiple risk factors.
- The interaction between structural/functional remodeling and cellular aging is significant.
- Lifestyle behaviors and cardiovascular health scores are identified as key modifiable targets.
Conclusions:
- Midlife presents a critical window for cardiovascular health interventions in women.
- Addressing lifestyle behaviors and cardiometabolic risk factors is essential for mitigating accelerated aging.
- Early preventive strategies can significantly support healthy cardiovascular aging.
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