[An experimental model of ischemic lesions of the small intestine]

Ischemic (necrotic) lesions of the small intestine are caused by the influence of elevated environment temperature on the rat. The initial change which was gained was a subnuclear vacuolization of the absorptive cells on the tips of the intestinal villi. Later on, the vacuoles blend into the subnuclear space which contains a serous exudate in some places. With the expansion of the subnuclear space the epithelium separates from the stroma, and after it's desquamation there comes to an autolysis of the denuded stroma of the intestinal villi. The lesions are comparable with lesions of the small intestine caused by hypothermia, shock, mesenterial blood vessel ligation in experimental models of other authors, and with ischemic lesions of the small intestine in humans as well. These changes can be considered as a nonspecific consequence of mesenterial ischemia in the appearance of which vascular factors play a key role.