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Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...

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Related Experiment Video

Updated: Jul 9, 2026

Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

[Paratuberculose enteritis and Crohn's disease].

Guillermo Suárez Fernández

    Anales De La Real Academia Nacional De Medicina
    |December 12, 2007
    PubMed
    Summary

    Paratuberculose enteritis, caused by Mycobacterium avium subsp. paratuberculosis, shares symptoms with Crohn's disease. This bacterium is increasingly found in Crohn's disease patients, suggesting a potential common etiology.

    Area of Science:

    • Veterinary Medicine
    • Human Gastroenterology
    • Microbiology

    Background:

    • Paratuberculose enteritis is a chronic, infectious ruminant disease characterized by diarrhea, emaciation, and intestinal inflammation.
    • Crohn's disease, a type of inflammatory bowel disease, exhibits similar ileitis and colitis with mucosal edema and transmural inflammation.
    • The etiological link between Mycobacterium avium subsp. paratuberculosis and Crohn's disease has been long suspected but difficult to prove.

    Purpose of the Study:

    • To explore the potential shared etiology between paratuberculose enteritis and Crohn's disease.
    • To review the evidence for the presence of Mycobacterium avium subsp. paratuberculosis in Crohn's disease patients.

    Main Methods:

    • Literature review and synthesis of existing research.

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  • Analysis of diagnostic methods including hemocultures, PCR, and in situ hybridization.

    • Main Results:

    • Mycobacterium avium subsp. paratuberculosis is the causative agent of paratuberculose enteritis in ruminants.
    • Significant pathological similarities exist between paratuberculose enteritis and Crohn's disease.
    • Increasing evidence demonstrates the frequent presence of Mycobacterium avium subsp. paratuberculosis in Crohn's disease patients.

    Conclusions:

    • The etiological similarity between paratuberculose enteritis and Crohn's disease warrants further investigation.
    • Mycobacterium avium subsp. paratuberculosis is a strong candidate for a common etiological factor in both diseases.