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Increased central aortic stiffness and left ventricular mass in normotensive young subjects after successful

Phalla Ou1, David S Celermajer, Odile Jolivet

  • 1Department of Pediatric Radiology, Hôpital Necker-Enfants Malades, University Rene Descartes-Paris 5, Paris, France. phalla.ou@nck.ap-hop-paris.fr

American Heart Journal
|December 18, 2007
PubMed

Insights

Successful aortic coarctation repair survivors show increased central aortic stiffness and elevated left ventricular mass, even without hypertension. This highlights the importance of monitoring central aortic function post-surgery.

Area of Science:

  • Cardiovascular Research
  • Pediatric Cardiology
  • Medical Imaging

Background:

  • Hypertension affects 20-40% of survivors with anatomically successful aortic coarctation (CoA) repair.
  • Central aortic function's role in this post-CoA repair setting requires further investigation.

Purpose of the Study:

  • To examine central aortic function in normotensive young adults after successful aortic coarctation repair.
  • To assess the relationship between aortic stiffness and left ventricular mass in these individuals.

Main Methods:

  • Magnetic resonance imaging (MRI) of the thoracic aorta and left ventricle in 40 CoA repair survivors and 20 controls.
  • Calculation of aortic distensibility, compliance, and stiffness beta index in central and descending aorta.
  • Measurement of aortic pulse wave velocity and left ventricular mass index.

Main Results:

  • CoA subjects exhibited significantly decreased central aortic distensibility and compliance, and increased stiffness beta index compared to controls.
  • Aortic pulse wave velocity was significantly higher in CoA subjects.
  • Left ventricular mass index was elevated in CoA subjects and correlated with aortic stiffness.

Conclusions:

  • Successful aortic coarctation repair is associated with markedly increased central aortic stiffness in normotensive young subjects.
  • Increased central aortic stiffness is linked to elevated left ventricular mass post-CoA repair.
Abstract

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