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Updated: Jul 9, 2026

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
Published on: September 6, 2017
Description of HLA-A*0127N, a novel nonexpressed allele identified by SBT
Elena Longhi1, Sara Frison, Emanuela Andreini
1Dipartimento di Medicina Rigenerativa, Immunologia dei Trapianti di Organi e Tessuti, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli, Regina Elena, Via Francesco Sforza 35, 20122 Milan, Italy.
Abstract:
We describe the isolation and characterization of a novel HLA-A null allele, officially named A*0127N. The A*0127N exon 2, 3, and 4 nucleotide sequence is identical to that of A*010101 except at position 553, where a G is substituted by a T, resulting in a coding change in exon 3 (GAG>TAG) from Glu to the stop codon AMB. The mutation described is responsible for the premature ending of the translation.
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