[Morphologic analysis of damage in renal grafts in various preservative solutions]

In this study experimental research was conducted concerning the morphology of renal lesions, in the function of time (12, 24, 36 and 48 hours) on potential renal allografts, which were stored in various cooled preservative fluids. A physiological solution was used, Euro-Collins and modified Euro-Collins, where dextrose was substituted with mannitol in the quantity of 35 g/l. With the modification of the Euro-Collins solution, in other words by the substitution of dextrose with mannitol, better results were achieved, and the differences grow in the function of time. The electrolytic content of this solution successfully maintains the intracellular ionic balance, and mannitol, as a highly osmotically active substance, offers better protection of the cells of the nephron complex from intracellular water penetration, which immediately results in the prolongation of preservation time and better quality of cadaveric renal graft.