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Related Concept Videos

Drug Discovery: Overview01:26

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
Preclinical Development: Overview01:28

Preclinical Development: Overview

Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
Structure-Activity Relationships and Drug Design01:28

Structure-Activity Relationships and Drug Design

Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence its...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Drug Administration and Therapy Phases: Overview01:26

Drug Administration and Therapy Phases: Overview

Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
Prodrugs01:30

Prodrugs

Prodrugs are a class of pharmaceutical compounds that undergo a biotransformation process within the body to be converted into a pharmacologically active drug. Prodrugs are designed to improve the therapeutic properties of the parent drug, such as enhancing bioavailability, increasing stability, or reducing toxicity. The concept of prodrugs revolves around modifying the chemical structure of the original drug to make it more effective or convenient for administration.
Prodrugs help overcome...

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Drug discovery and development with plant-derived compounds.

Olivier Potterat1, Matthias Hamburger

  • 1University of Basel, Institute of Pharmaceutical Biology, Klingelbergstrasse 50, 4056 Basel, Switzerland.

Progress in Drug Research. Fortschritte Der Arzneimittelforschung. Progres Des Recherches Pharmaceutiques
|December 19, 2007
PubMed
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Plant-derived natural products are advancing in drug development for various diseases, including cancer and HIV. This overview highlights clinical progress and unique challenges in plant-based drug discovery.

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Area of Science:

  • Pharmacology
  • Natural Products Chemistry
  • Drug Discovery

Background:

  • Plant-derived natural products have historically been a rich source of therapeutic agents.
  • Modern drug discovery increasingly explores these compounds for novel treatments.
  • Advancements in technology facilitate the identification and development of plant-based drugs.

Purpose of the Study:

  • To provide an overview of current drug development efforts utilizing plant-derived natural products.
  • To emphasize projects that have progressed to clinical development stages.
  • To address specific challenges and considerations in plant-based drug discovery.

Main Methods:

  • Literature review of ongoing drug development projects.
  • Analysis of therapeutic areas where plant-derived compounds are in clinical trials.
  • Discussion of commercialization and regulatory aspects.

Main Results:

  • Numerous plant-derived natural products are in various phases of clinical development.
  • Therapeutic areas include oncology, infectious diseases (HIV, malaria), inflammation, and neurodegenerative disorders.
  • Vaccine adjuvants and metabolic disorder treatments are also emerging.

Conclusions:

  • Plant-derived natural products represent a significant and promising avenue for drug development.
  • Clinical progression indicates the therapeutic potential of these compounds.
  • Addressing supply chain and biodiversity conventions is crucial for sustainable development.