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Updated: Jul 9, 2026

Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods
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Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods

Published on: July 17, 2019

Src kinase and pancreatic cancer

A Hilbig1

  • 1Charité-Universitätsmedizin Berlin, Campus Virchow-Klinikum, Medizinische Klinik mit Schwerpunkt Hämatologie und Onkologie, Germany.

Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progres Dans Les Recherches Sur Le Cancer
|December 19, 2007
PubMed

Insights

The c-Src tyrosine kinase is overexpressed in many cancers, driving tumor growth and metastasis. New targeted therapies are being developed and are currently in clinical trials.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • The c-Src non-receptor tyrosine kinase is frequently overexpressed in various human malignancies.
  • c-Src plays a critical role in promoting tumor development, invasion, and metastasis.

Purpose of the Study:

  • To highlight the role of c-Src in cancer progression.
  • To discuss the development of novel c-Src-targeted anticancer therapeutics.

Main Methods:

  • Review of existing literature on c-Src function in cancer.
  • Analysis of clinical trial data for c-Src inhibitors.

Main Results:

  • c-Src overexpression correlates with increased tumor proliferation, invasion, and motility.
  • Emerging therapeutics targeting c-Src show promise in preclinical and clinical settings.

Conclusions:

  • c-Src is a significant driver of cancer progression and metastasis.
  • Targeting c-Src represents a promising therapeutic strategy for various human cancers.

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