Related Experiment Video
Updated: Jul 9, 2026
Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass Graft
Published on: September 15, 2023
[Value of left ventricular ejection fraction in coronary artery bypass grafting patients]
1Department of Cardiac Surgery, Peking University First Hospital, Beijing 100034, China.
Insights
Left ventricular ejection fraction (LVEF) below 0.40 is a significant risk factor in coronary artery bypass grafting (CABG) patients. Despite higher risks, surgical outcomes for these patients are satisfactory, with improved LVEF post-operation.
Area of Science:
- Cardiology
- Cardiac Surgery
Background:
- Assessing left ventricular ejection fraction (LVEF) is crucial for risk stratification in patients undergoing coronary artery bypass grafting (CABG).
- Low LVEF may indicate underlying cardiac conditions requiring simultaneous surgical intervention.
Purpose of the Study:
- To evaluate the prognostic role of LVEF in patients undergoing CABG.
- To compare outcomes between patients with low LVEF (<0.40) and normal LVEF (>0.40) undergoing CABG.
Main Methods:
- A retrospective analysis of 215 patients who underwent CABG between 2004 and 2005.
- Patients were divided into a low LVEF group (n=36) and a normal LVEF group (n=179).
- Statistical comparison of preoperative risk factors, intraoperative findings, and postoperative outcomes.
Main Results:
- The low LVEF group had a significantly higher EuroSCORE and a higher prevalence of concomitant mitral valve insufficiency and aneurysm requiring simultaneous surgery (55.6%).
- In-hospital mortality was higher in the low LVEF group (5.5%) compared to the normal LVEF group (2.8%, P<0.05).
- Postoperative LVEF significantly improved in the low LVEF group (mean 0.47+/-0.11, P<0.05), with 94.5% of survivors free of angina.
Conclusions:
- LVEF < 0.40 is confirmed as a risk factor in CABG patients, often associated with complex cardiac conditions.
- Simultaneous surgical correction of mitral valve insufficiency and aneurysm in these patients is frequently necessary.
- Early surgical results for patients with low LVEF undergoing CABG are encouraging, with significant functional improvement observed.
Objective:
To evaluate the role of the left ventricular ejection fraction (LVEF) in coronary artery bypass grafting(CABG)patients.
Methods:
From 2004 to 2005,215 patients underwent CABG and there were 36 cases with LVEF<0.40(low LVEF group) whereas 179 cases with LVEF>0.40(normal LVEF group). Correlative data of the two groups were compared and analyzed statistically.
Results:
Compared with the normal EF group, the EuroSCORE of the low EF group was much higher (mean 6.4+/-1.7) and many more patients of the low EF group had concomitant moderate to severe mitral valve insufficiency and aneurysm that needed simultaneous surgical operation(55.6%).Two patients died in hospital(5.5%)in the low EF group whereas five patients in the normal EF group(2.8%, P<0.05).In the low EF group,34 survivors(94.5%)were free of angina. Low cardiac output was the main postoperative complication. The mean EF was significantly improved postoperatively (mean 0.47+/-0.11)(P<0.05).
Conclusion:
EF<0.40 is indeed a risk factor for patients with coronary artery disease. Most of them have concomitant moderate to severe mitral valve insufficiency and aneurysm that need simultaneous surgical operations. The early surgical result of them is of satisfaction.
