Related Experiment Video
Updated: Jul 9, 2026
Intramyocardial Cell Delivery: Observations in Murine Hearts
Published on: January 24, 2014
[Intracoronary transfer autologous bone marrow stem cells can improve cardiac function in patients with left
Ying Nie1, Yan Hong Guo, Li Jun Guo
1Department of Cardiology, Peking University Third Hospital and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing 100083, China.
Insights
Bone marrow mononuclear stem cell transplantation improved heart function in patients post-myocardial infarction. This therapy enhanced myocardial perfusion and reduced heart failure symptoms, offering a promising treatment option.
Area of Science:
- Regenerative Medicine
- Cardiovascular Research
- Stem Cell Therapy
Background:
- Myocardial infarction (MI) frequently leads to heart dysfunction and heart failure.
- Current treatments for post-MI heart dysfunction have limitations.
Purpose of the Study:
- To assess the efficacy of intracoronary autologous bone marrow mononuclear stem cells (BMSC) in patients with heart dysfunction post-MI.
Main Methods:
- 42 patients with anterior MI received standard percutaneous coronary intervention (PCI) and medical therapy.
- The BMSC group (13 patients) received additional intracoronary BMSC transplantation.
- Evaluations included NYHA class, NT-proBNP levels, 6-minute walk test, and SPECT imaging at baseline and 12 months.
Main Results:
- BMSC group showed significant improvements in NYHA class and reduced NT-proBNP levels compared to the control group.
- Myocardial blood perfusion scores improved significantly in the BMSC group.
- SPECT revealed reduced perfusion defect areas in the BMSC group, though global LVEF did not show significant change.
Conclusions:
- Intracoronary BMSC transplantation is effective in improving myocardial blood perfusion and systolic function in heart failure patients post-MI.
- This stem cell therapy represents a potential advancement in managing post-myocardial infarction cardiac dysfunction.
Objective:
To evaluate the efficacy of intracoronary transfer of autologous bone marrow mononuclear stem cells in patients with heart dysfunction after myocardial infarction.
Methods:
Forty-two patients with anterior myocardial infarction [BMSC(bone marrow mononuclear stem cells) group: 13 cases; control group: 29 cases] were treated by standard percutaneous coronary intervention (PCI) and medical therapy. Patients in BMSC group were also transplanted bone marrow mononuclear stem cells through coronary injection. Baseline and 12 months' follow-up evaluations included New York Heart Association Class ( NYHA class) and the level of plasma NT-proBNP, six minutes walk test, single photon emission computed tomography(SPECT).
Results:
In BMSC group, the NYHA class improved significantly at the end of the 12 months' follow-up (1.54+/-0.27 vs. 2.62+/-0.33, P=0.002) and was better than that of control group (2.45+/-0.21, P=0.02). The level of plasma NTjproBNP reduced significantly [(701.05+/-154.60) ng/L vs. (1,921.70+/-373.70) ng/L, P=0.000 8]. The distances of six minutes walk test of the two groups increased significantly [BMSC group: (432.85+/-27.81) m vs. (363.77+/-20.14) m, P=0.000 6;control group: (381.48+/-17.72) m vs. (339.00+/-9.87) m, P=0.000 5], but the difference was not obvious between the two groups. The score of myocardial blood perfusion improved significantly in BMSC group at the end of the 12 months' follow-up (31.15+/-3.65 vs. 46.31+/-2.87, P=0.002) and was better than that of control group (42.59+/-2.08,P=0.015 7). The area of the perfusion defects in SPECT reduced significantly in BMSC group [(32.23+/-4.40)% vs. (39.54+/-3.76)%, P=0.000 1], but no obvious difference was found between the two groups. Global LVEF of BMSC group increased [(38.54+/-2.94)% vs. (35.38+/-2.16)%, P>0.05).
Conclusion:
Intracoronary transplantation of bone marrow mononuclear cells could improve myocardial blood perfusion and increase the systolic function in patients with heart failure after myocardial infarction.
More Related Videos
07:50Delayed Intramyocardial Delivery of Stem Cells after Ischemia Reperfusion Injury in a Murine Model
Published on: September 3, 2020
09:16Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes
Published on: June 3, 2018
Related Concept Videos
01:21Stem Cell Therapy for Tissue Regeneration
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
01:22Bone Marrow Sampling and Transplants
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
01:29Cardiomyopathy V: Interprofessional Care