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Two new triterpene glycosides from the Vietnamese sea cucumber Holothuria scabra
Nguyen Hai Dang1, Nguyen Van Thanh, Phan Van Kiem
1Institute of Natural Products Chemistry, Vietnamese Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam.
Abstract:
Two new triterpene glycosides, namely holothurin A3 (1) and A4 (2) were isolated from the methanol extract of the sea cucumber, Holothuria scabra, with their structures elucidated from the spectroscopic evidence (1D NMR, 2D NMR, ESI-MS and HRESI-MS). Compounds 1 and 2 were found to be strongly cytotoxic to both cancer cell lines, KB and Hep-G2, with 50% inhibitory concentrations (IC50) of 0.87 and 0.32 microg/mL (for compound 1) and of 1.12 and 0.57 microg/mL (for compound 2), respectively.
