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Related Experiment Video

Updated: Jul 9, 2026

High-Throughput In Vitro Assay using Patient-Derived Tumor Organoids

High-Throughput In Vitro Assay using Patient-Derived Tumor Organoids

Published on: June 14, 2021

Acneiform eruption induced by cetuximab.

Claudia Cotena¹, Paolo Gisondi, Chiara Colato

¹Department of Biomedical and Surgical Science, University of Verona, Verona, Italy.

Acta Dermatovenerologica Croatica : ADC

|December 21, 2007

Summary

Cetuximab treatment for metastatic colorectal cancer can cause acneiform eruptions. This case study shows successful management of this side effect with antibiotics, allowing continued cancer therapy.

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Last Updated: Jul 9, 2026

High-Throughput In Vitro Assay using Patient-Derived Tumor Organoids

High-Throughput In Vitro Assay using Patient-Derived Tumor Organoids

Published on: June 14, 2021

Area of Science:

Oncology
Dermatology
Pharmacology

Background:

Cetuximab, a monoclonal antibody targeting epidermal growth factor receptor (EGFR), is used for metastatic colorectal cancer.
Cutaneous reactions, primarily acneiform eruptions, are common side effects of cetuximab therapy.
EGFR plays a crucial role in maintaining skin homeostasis.

Observation:

A 46-year-old female patient with metastatic colorectal cancer developed an intense acneiform eruption after initiating cetuximab and irinotecan treatment.
The eruption presented as erythematous follicular papules and pustules on the face, neck, and upper trunk, accompanied by pruritus and fever.
Skin biopsy confirmed superficial and florid neutrophilic suppurative folliculitis without comedones.

Findings:

The patient was treated with oral erythromycin and topical clindamycin.
After one month of antibiotic treatment, the acneiform eruption significantly improved.
Histopathological findings indicated neutrophilic suppurative folliculitis.

Implications:

Antibiotic therapy can effectively manage cetuximab-induced acneiform eruptions.
Successful management of skin toxicity allows for the continuation of essential immunochemotherapy for metastatic colorectal cancer.
This highlights the importance of addressing adverse cutaneous events to maintain treatment adherence and efficacy.