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Updated: Jul 9, 2026
Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures
Published on: January 9, 2019
Molecular and genetic profiling in human gliomas
Kamalakannan Palanichamy1, Michael Erkkinen, Gregory Saia
1Department of Radiation Oncology, Massachusetts General Hospital/Harvard Medical School, 100 Blossom Street, Cox 3, Boston, MA 02114, USA.
Abstract:
Glioblastoma multiforme is the most aggressive fatal brain tumor with a median survival of about a year after diagnosis. The current available treatment options only marginally improve patient outcome. The complexity and heterogeneity of the disease pose an extensive challenge to the development of novel therapeutic agents. Through molecular and genetic profiling, it has been possible to both identify mechanisms of disease progression and its therapeutic resistance. This paper highlights the significance of these advances.
Insights
Glioblastoma multiforme, a deadly brain tumor, has limited treatment options. Molecular and genetic profiling are advancing understanding of its progression and resistance, paving the way for new therapies.
Area of Science:
- Neuro-oncology
- Cancer Genomics
- Molecular Pathology
Background:
- Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor.
- Current treatments offer limited survival benefits for GBM patients.
- The tumor's complexity and heterogeneity present significant therapeutic challenges.
Purpose of the Study:
- To highlight advances in understanding glioblastoma multiforme.
- To underscore the importance of molecular and genetic profiling in GBM research.
- To emphasize the potential for novel therapeutic development.
Main Methods:
- Review of current literature on glioblastoma multiforme.
- Analysis of molecular and genetic profiling techniques.
- Synthesis of findings related to disease progression and therapeutic resistance.
Main Results:
- Molecular and genetic profiling have identified key mechanisms driving GBM progression.
- These profiling techniques reveal insights into therapeutic resistance in GBM.
- Advances facilitate the identification of potential therapeutic targets.
Conclusions:
- Molecular and genetic profiling are crucial for advancing glioblastoma research.
- Understanding GBM complexity is key to developing more effective treatments.
- These advances offer hope for improved patient outcomes in glioblastoma.
