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Assessment of Ultrasonic Vocalizations During Drug Self-administration in Rats
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[Evaluation of Viva-E drug testing system].

Hae-Sun Chung1, Seung-Tae Lee, Soo-Youn Lee

  • 1Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

The Korean Journal of Laboratory Medicine
|December 21, 2007
PubMed
Summary

The Viva-E Drug Testing System demonstrates excellent analytical performance for therapeutic drug monitoring (TDM), offering a wide drug menu and efficient analysis. This makes it a valuable tool for clinical laboratories needing reliable drug level measurements.

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Area of Science:

  • Clinical Chemistry
  • Laboratory Medicine
  • Pharmacology

Background:

  • Therapeutic drug monitoring (TDM) is crucial for optimizing patient treatment.
  • Increased demand for drug analysis in clinical laboratories necessitates efficient instrumentation.
  • The Viva-E Drug Testing System (Dade Behring Inc.) is a new immunoassay instrument for TDM.

Purpose of the Study:

  • To evaluate the analytical performance of the Viva-E system.
  • To assess the clinical usefulness of the Viva-E system for TDM.
  • To compare Viva-E performance against established methods.

Main Methods:

  • Analytical performance (linearity, precision, correlation) assessed using patient samples and controls for 11 drugs.
  • Comparison with Cobas Integra 800 and API 4000 LC-MS/MS systems.
  • Analysis time was also evaluated.

Main Results:

  • Viva-E demonstrated good linearity (r2 ≥ 0.97) for all tested drugs.
  • Precision was acceptable (within-run CVs <5%, total CVs <10%) for most drugs.
  • Strong correlations (r=0.9283-0.9778) were observed with other methods.

Conclusions:

  • Viva-E exhibits strong analytical performance (linearity, precision, accuracy) for TDM.
  • Its comprehensive drug menu and efficient functions support its utility in clinical labs.
  • The system is a valuable asset for diverse TDM needs in clinical settings.