[A field study on the post-inoculation reaction and immunological effects in vaccinated population immunized with...

A comparative study on the post-inoculation and antibody responses after inoculation with two different dosage (1ml, 2ml) of "zhejiang type-D" leptospiral vaccine was carried out. There was no general reaction in all of the vaccinated people after immunization. The GMT values of antibody against leptospire were 3.08-7.91 times in 1ml dose group and 3.48-9.57 times in 2ml dose group more than pre-vaccination respectively. 3 months after immunization the levels of specific antibody still were high in most vaccinated people, whatever in 1ml dose or 2ml dose of immunization. However the antibody couldn't be detected in part of vaccinated people at that time, but there was no difference between the two different dosages. During the epidemic season, there was no leptospirosis case (0/3260) in the 1ml group, 1 case (1/625) in the 2 ml group while there was 9/3970 in the control group.