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An anaphylactic reaction to protamine sulfate
1Department of Maxillo-Facial Surgery, University of Stellenbosch, Tygerberg, South Africa.
Anesthesia Progress
|May 1, 1991
Summary
Protamine sulfate can cause immediate allergic-like reactions, including severe drops in blood pressure and swelling. Skin testing confirmed a positive reaction to protamine sulfate in this patient.
Area of Science:
- Cardiology
- Anesthesiology
- Immunology
Background:
- Protamine sulfate is used to reverse heparin's anticoagulant effects after cardiac surgery.
- Previous exposure to protamine may increase the risk of adverse reactions.