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Updated: Jul 8, 2026

Induction of Graft-versus-host Disease and In Vivo T Cell Monitoring Using an MHC-matched Murine Model

Induction of Graft-versus-host Disease and In Vivo T Cell Monitoring Using an MHC-matched Murine Model

Published on: August 29, 2012

Oral graft-versus-host disease.

Mark M Schubert¹, Maria Elvira Pizzigatti Correa

¹Oral Medicine Service, Fred Hutchinson Cancer Research Center, Seattle Cancer Care Alliance, 825 Eastlake Avenue East, Seattle, WA 98109, USA. mschuber@seattlecca.org

Dental Clinics of North America

|December 25, 2007

Summary

Hematopoietic cell transplantation can lead to graft-versus-host disease (GVHD), a serious complication affecting various tissues. Oral GVHD management is crucial for patient function and quality of life.

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Published on: March 17, 2020

Area of Science:

Hematology
Immunology
Oncology

Background:

Hematopoietic cell transplantation (HCT) treats various diseases, including malignancies and immune disorders.
Graft-versus-host disease (GVHD) is a major complication of allogeneic HCT, involving donor T cells attacking host tissues.
Oral GVHD presents with symptoms similar to autoimmune diseases, impacting oral function and patient quality of life.

Purpose of the Study:

To highlight the significance of oral GVHD in the context of HCT.
To emphasize the role of oral GVHD recognition, diagnosis, and monitoring.
To discuss the benefits of topical and local management strategies for oral GVHD.

Main Methods:

Clinical observation and diagnosis of oral GVHD.
Monitoring of GVHD progression and response to therapy.
Application of topical and local management interventions.

Main Results:

Oral GVHD is a common manifestation following HCT.
Accurate diagnosis and grading of oral GVHD aid in overall GVHD management.
Local management effectively alleviates oral symptoms and improves quality of life.

Conclusions:

Oral GVHD requires careful recognition and management.
Effective management of oral GVHD can reduce systemic immunosuppression needs.
Addressing oral symptoms improves patient function and quality of life post-HCT.