Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Metastasis

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

Metastasis

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Analysis of genetic predisposition to familial non-medullary thyroid cancer by whole genome sequencing.

Annales d'endocrinologie·2025

Same author

Disintegrin-like Protein Strategy to Inhibit Aggressive Triple-Negative Breast Cancer.

International journal of molecular sciences·2023

Same author

Genetic predisposition to neural crest-derived tumors: revisiting the role of KIF1B.

Endocrine connections·2020

Same author

The conundrum of dietary antioxidants in cancer chemotherapy.

Nutrition reviews·2019

Same author

A Full Phenotype of Paraganglioma Linked to a Germline SDHB Mosaic Mutation.

The Journal of clinical endocrinology and metabolism·2019

Same author

Optimization of Next-Generation Sequencing Technologies for von Hippel Lindau (VHL) Mosaic Mutation Detection and Development of Confirmation Methods.

The Journal of molecular diagnostics : JMD·2019

Search research articles

Related Experiment Video

Updated: Jul 8, 2026

Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells

Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells

Published on: August 2, 2022

[Metastatic process and therapies].

Michel Crépin¹

¹Université de Paris 13, SMBH, 93017 Bobigny, Inserm U553, Hopital Saint-Louis, 75010 Paris. crepin@smbh.univ-paris13.fr

Journal De La Societe De Biologie

|December 25, 2007

Summary

Understanding tumor progression is advancing, but the mechanisms of cancer metastasis remain unclear. New therapies require better animal models and integrated research to target this complex disease effectively.

Area of Science:

Oncology and Cancer Biology
Molecular and Cellular Biology
Translational Medicine

Context:

While tumor progression is increasingly understood at cellular and molecular levels, the intricate mechanisms driving cancer metastasis are not well elucidated.
Significant knowledge gaps persist, hindering the development of effective therapeutic strategies against metastatic disease.
There is a critical need for experimental animal models that accurately recapitulate human metastatic processes.

Purpose:

To review the current understanding of tumor progression and metastasis.
To highlight unresolved questions in metastatic mechanisms.
To emphasize the necessity of advanced animal models and integrated research for discovering novel therapeutic targets.

Summary:

This domain review synthesizes current knowledge on tumor progression, contrasting it with the poorly understood mechanisms of cancer metastasis.

More Related Videos

In Vivo Imaging to Measure Spontaneous Lung Metastasis of Orthotopically-injected Breast Tumor Cells

In Vivo Imaging to Measure Spontaneous Lung Metastasis of Orthotopically-injected Breast Tumor Cells

Published on: June 23, 2022

Generation of Organ-conditioned Media and Applications for Studying Organ-specific Influences on Breast Cancer Metastatic Behavior

Generation of Organ-conditioned Media and Applications for Studying Organ-specific Influences on Breast Cancer Metastatic Behavior

Published on: June 13, 2016

Related Experiment Videos

Last Updated: Jul 8, 2026

Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells

Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells

Published on: August 2, 2022

In Vivo Imaging to Measure Spontaneous Lung Metastasis of Orthotopically-injected Breast Tumor Cells

In Vivo Imaging to Measure Spontaneous Lung Metastasis of Orthotopically-injected Breast Tumor Cells

Published on: June 23, 2022

Generation of Organ-conditioned Media and Applications for Studying Organ-specific Influences on Breast Cancer Metastatic Behavior

Generation of Organ-conditioned Media and Applications for Studying Organ-specific Influences on Breast Cancer Metastatic Behavior

Published on: June 13, 2016

It identifies key unanswered questions crucial for advancing anti-metastatic therapies.

The importance of developing and utilizing experimental animal models that mimic human metastatic disease is stressed, alongside the need for combined pathological and clinical research.

Impact:

Advances the understanding of cancer metastasis, a critical factor in patient mortality.
Identifies crucial areas for future research in oncology.
Facilitates the discovery of new therapeutic targets and strategies to combat metastatic cancer.
Promotes interdisciplinary collaboration between basic science, pathology, and clinical research.