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Updated: Jul 8, 2026

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
Published on: June 13, 2022
An efficient and expeditious synthesis of di- and monosubstituted 2-aminoimidazoles
Chai Hoon Soh1, Wai Keung Chui, Yulin Lam
1Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore.
Abstract:
A microwave-assisted protocol was developed for the construction of di- and monosubstituted 2-aminoimidazoles. The two-step reaction involves the synthesis of N-(1H-imidazol-2-yl)acetamides from readily available alpha-haloketones and N-acetylguanidine, followed by deacetylation. Significant rate enhancement was observed for both steps of the protocol, and the overall reaction time was shortened to 20 min compared to 48 h of the conventional procedures. A representative set of di- and monosubstituted 2-aminoimidazoles was prepared using commercially available parallel reactors.
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