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Updated: Jul 27, 2025

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
Published on: November 30, 2022
Development of fluorous boronic acid catalysts integrated with sulfur for enhanced amidation efficiency
Kevin Timothy Fridianto1, Ya-Ping Wen2, Lee-Chiang Lo2
1Department of Chemistry, National University of Singapore 3 Science Drive 3 Singapore 117543 chmlamyl@nus.edu.sg.
Abstract:
A thermally stable, fluorous sulfur-containing boronic acid catalyst has been developed and was shown to efficiently promote dehydrative condensation between carboxylic acids and amines under environmentally friendly conditions. The methodology can be applied to aliphatic, aromatic and heteroaromatic acids as well as primary and secondary amines. N-Boc protected amino acids were also successfully coupled in good yields with very little racemization. The catalyst could be reused four times with no significant loss of activity.
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