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Related Experiment Video

Updated: Jul 8, 2026

Non-Invasive Electrical Brain Stimulation Montages for Modulation of Human Motor Function
07:47

Non-Invasive Electrical Brain Stimulation Montages for Modulation of Human Motor Function

Published on: February 4, 2016

Motor cortex stimulation for pain and movement disorders.

Jeffrey E Arle1, Jay L Shils

  • 1Department of Neurosurgery, Lahey Clinic, Burlington, Massachusetts 01805, USA. Jeffrey.arle@lahey.org

Neurotherapeutics : the Journal of the American Society for Experimental Neurotherapeutics
|January 1, 2008
PubMed
Summary

Motor cortex stimulation (MCS) effectively treats chronic pain and movement disorders like Parkinson's disease. Our research explores its mechanisms and clinical applications in various neurological conditions.

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Area of Science:

  • Neurology
  • Neurosurgery
  • Computational Neuroscience

Background:

  • Motor cortex stimulation (MCS) has been utilized since the early 1990s.
  • Initial applications focused on chronic refractory pain and movement disorders.
  • Literature review (1991-2007) identified 512 MCS cases, predominantly for pain (422) but also movement disorders (84).

Purpose of the Study:

  • To review the history and clinical applications of MCS.
  • To present case series of patients treated with MCS for pain and movement disorders.
  • To investigate the underlying mechanisms of MCS using computational modeling.

Main Methods:

  • Medline literature search (1991-2007).
  • Retrospective case series analysis of patients treated with MCS.

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Last Updated: Jul 8, 2026

Non-Invasive Electrical Brain Stimulation Montages for Modulation of Human Motor Function
07:47

Non-Invasive Electrical Brain Stimulation Montages for Modulation of Human Motor Function

Published on: February 4, 2016

Measuring and Manipulating Functionally Specific Neural Pathways in the Human Motor System with Transcranial Magnetic Stimulation
09:52

Measuring and Manipulating Functionally Specific Neural Pathways in the Human Motor System with Transcranial Magnetic Stimulation

Published on: February 23, 2020

Utilizing Transcranial Magnetic Stimulation to Study the Human Neuromuscular System
12:19

Utilizing Transcranial Magnetic Stimulation to Study the Human Neuromuscular System

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  • Development of computational models to explore MCS mechanisms.

    • Main Results:

    • MCS has been applied to diverse conditions including post-stroke pain, Parkinson's disease (PD), essential tremor (ET), and corticobasal degeneration.
    • Case series included 8 patients with pain/movement disorders, 4 with PD, 2 with ET, and 1 with corticobasal degeneration.
    • Ongoing research utilizes computational modeling to elucidate MCS mechanisms.

    Conclusions:

    • MCS is a viable therapeutic option for refractory pain and specific movement disorders.
    • Further research, including computational modeling, is crucial for understanding MCS mechanisms.
    • MCS demonstrates potential in managing complex neurological conditions like PD and ET.