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Schilder's diffuse sclerosis.

J J Martin1, G C Guazzi

  • 1Born-Bunge Foundation, University of Antwerp, Belgium.

Developmental Neuroscience
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

Schilder's disease is a heterogeneous group of neurological disorders. Advances in clinical and genetic studies confirm this, suggesting avoiding the term "Schilder's disease" to prevent confusion.

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Area of Science:

  • Neurology
  • Neuroscience
  • Pathology

Background:

  • Schilder's diffuse sclerosis concept described in 1956.
  • Subsequent clinical, genetic, enzymatic, and biochemical studies reveal heterogeneity.

Purpose of the Study:

  • To review the historical context and evolution of Schilder's disease.
  • To discuss the classification and differentiation of related neurological disorders.

Main Methods:

  • Literature review of historical and contemporary studies.
  • Analysis of clinical, genetic, and biochemical data.
  • Categorization of myelinoclastic disorders and leukodystrophies.

Main Results:

  • Schilder's disease encompasses heterogeneous conditions.

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  • Key disorders include myelinoclastic disorders, adrenoleukodystrophy, sudanophilic leukodystrophies, and subacute sclerosing panencephalitis.

    • Conclusions:

    • The term "Schilder's disease" should be avoided due to diagnostic ambiguity.
    • Accurate classification aids in understanding and managing these distinct neurological conditions.