Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

B cells flying solo.

Joanna Groom¹, Fabienne Mackay

¹The Autoimmunity Research Unit, The Garvan Institute of Medical research, Darlinghurst, New South Wales, Australia.

Immunology and Cell Biology

|January 4, 2008

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Circulating metabolomic profile and its association with atrial fibrillation and systemic inflammation.

Heart rhythm O2·2026

Same author

Communicating science.

Immunity·2026

Same author

Macrophage migration inhibitory factor induces phospholamban phosphorylation in cardiac muscle.

Cell calcium·2025

Same author

An unappreciated cell survival-independent role for BAFF initiating chronic lymphocytic leukemia.

Frontiers in immunology·2024

Same author

Gut Microbiota and Atrial Fibrillation: Pathogenesis, Mechanisms and Therapies.

Arrhythmia & electrophysiology review·2023

Same author

The BAFF-APRIL System in Cancer.

Cancers·2023

Same journal

Ancestry Matters in Decoding Immunity.

Immunology and cell biology·2026

Same journal

Improving COVID-19 Vaccine Uptake Among Ethnic Minority Communities in Wales: A Community-Based Approach.

Immunology and cell biology·2026

Same journal

4-1BB Expression and Signaling Regulates MAIT Cell Activation and Effector Functions.

Immunology and cell biology·2026

Same journal

Highlights of 2025: Advances in the T-Cell Regulation of Germinal Center Response.

Immunology and cell biology·2026

Same journal

The Role of the IL-33/ST2 Axis in Nervous System Development and Diseases.

Immunology and cell biology·2026

Same journal

Bridging Science and Society: Public Engagement as a Catalyst for Infectious Disease Control and Prevention.

Immunology and cell biology·2026

See all related articles

Systemic lupus erythematosus (SLE) can develop from innate B-cell activation, independent of T-cells. This finding reveals a new mechanism driving autoimmune diseases like SLE.

Area of Science:

Immunology
Autoimmunity
Rheumatology

Background:

Systemic autoimmunity, like systemic lupus erythematosus (SLE), involves B-cell tolerance loss, dysregulation, and autoantibody production.
While autoantibodies contribute to SLE pathology, T-cell dysregulation is also a critical driver of the disease.
T-cell and B-cell cooperation is believed to underlie disease progression in many SLE patients.

Purpose of the Study:

To investigate the role of T-cells in SLE pathogenesis in BAFF-overexpressing mice.
To explore alternative pathogenic mechanisms in SLE beyond T-cell and B-cell cooperation.

Main Methods:

Utilized BAFF transgenic (Tg) mice, comparing T-cell-sufficient and T-cell-deficient models.
Analyzed the development of SLE and associated autoantibody production in these models.

Related Experiment Videos

Main Results:

T-cell-deficient BAFF Tg mice developed SLE, mirroring disease progression in T-cell-sufficient counterparts.
The observed SLE in T-cell-deficient mice was linked to innate B-cell activation and proinflammatory autoantibody production.

Conclusions:

Dysregulated innate activation of B cells can independently drive SLE pathogenesis, irrespective of T-cell involvement.
This discovery presents a novel pathogenic mechanism in autoimmunity, highlighting innate B-cell activation as a key factor in SLE development.