[Diastolic dysfunction and diastolic heart failure]

Area of Science:

• Cardiology
• Heart Failure Pathophysiology

Context:

• Diastolic dysfunction is frequently observed in clinical cardiology, often leading to heart failure with preserved systolic function.
• Diagnosis of diastolic heart failure is frequently made by exclusion, indicating a need for more definitive diagnostic methods.
• Epidemiological data, such as from Framingham, show a high prevalence of clinically manifested diastolic dysfunction, particularly in aging populations and women.

Purpose:

• To review current research on the pathogenesis, diagnosis, and treatment of heart diastolic insufficiency.
• To underscore the clinical and social significance of diastolic heart failure.
• To highlight the need for improved understanding and management strategies.

Summary:

• Heart failure can occur with normal left ventricular systolic function, a condition diagnosed as diastolic heart failure.
• This diagnosis is often reached through exclusion, suggesting limitations in current diagnostic approaches.
• The prevalence increases with age and is higher in women, presenting a significant public health challenge.

Impact:

• Improved diagnostic accuracy for diastolic heart failure.
• Development of targeted therapeutic strategies for patients with preserved systolic function.
• Enhanced understanding of the epidemiology and pathophysiology of diastolic heart failure, particularly in aging women.