Related Experiment Video
Updated: Jul 8, 2026
10:10
Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
Published on: November 8, 2016
T cells in psoriatic arthritis.
1Academic Department of Rheumatology, King's College London, Weston Education Center, Cutcombe Road, London, SE5 9PJ, UK. ernest.choy@kcl.ac.uk
Current Rheumatology Reports
|January 8, 2008
Summary
Psoriatic arthritis involves chronic inflammation driven by T cells in the skin and joints. Evidence suggests these T cells are activated by specific antigens, highlighting their key role in disease progression and joint damage.
Area of Science:
- Immunology
- Rheumatology
- Dermatology
Background:
- Psoriatic arthritis (PsA) is a chronic inflammatory condition affecting skin and joints.
- T cells are prevalent in inflamed PsA tissues.
- Major histocompatibility complex (MHC) plays a role in PsA susceptibility by presenting antigens.
Purpose of the Study:
- To investigate the role of T cells in the pathogenesis of psoriatic arthritis.
- To explore the evidence for antigen-driven T-cell activation in PsA.
Main Methods:
- Analysis of T cell phenotype and T-cell receptor (TCR) usage in synovial joints.
- Review of disease susceptibility associations with MHC.
- Evaluation of therapeutic responses to anti-T-cell agents.
Main Results:
- T cells in PsA synovial joints exhibit an activated phenotype.
- Selective TCR usage indicates T-cell clonal expansions.
- MHC association suggests antigen presentation is crucial.
Conclusions:
- Psoriatic arthritis pathogenesis is likely driven by antigen-specific T-cell activation.
- T cells play a critical role in the persistent inflammation and joint damage seen in PsA.
- The efficacy of anti-T-cell therapies supports this conclusion.
Related Concept Videos
01:24T Cell Types and Functions
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
01:22T Cell Activation and Clonal Selection
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
01:20The JAK-STAT Signaling Pathway
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...