Related Experiment Video

Updated: Jul 8, 2026

Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice
06:39

Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice

Published on: April 13, 2015

Systolic and diastolic dyssynchrony are unaffected by revascularization of viable, dysfunctional myocardium

Sadia N Khan1, Linda D Sharples, Patrick M Heck

  • 1Department of Cardiology, Addenbrooke's Hospital, Hills Road, Cambridge, United Kingdom.

Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography
|January 12, 2008
PubMed

Insights

Resting dyssynchrony in patients with ischemic heart failure showed minimal change with dobutamine stress or after revascularization procedures. This suggests current treatments may not significantly impact this specific measure of cardiac function.

Area of Science:

  • Cardiology
  • Cardiac Imaging
  • Heart Failure Research

Background:

  • Limited data exists on how cardiac dyssynchrony changes during stress or following revascularization.
  • Ischemic left ventricular dysfunction is a significant clinical concern.

Purpose of the Study:

  • To investigate the impact of dobutamine stress and revascularization on cardiac dyssynchrony in patients with viable, dysfunctional myocardium.
  • To assess changes in dyssynchrony indices (T-sd(c)) before and after revascularization.

Main Methods:

  • Tissue Doppler echocardiography with dobutamine stress was employed in 25 patients with ejection fraction <= 35% and QRS duration <= 120 msec.
  • Dyssynchrony indices (T-sd(c)) were measured at baseline and 6 months post-revascularization.

Main Results:

  • Dobutamine stress induced minimal changes in resting systolic and diastolic T-sd(c) at baseline.
  • No significant overall difference in mean T-sd(c) was observed 6 months after revascularization.
  • A modest improvement in systolic T-sd(c) was noted at follow-up (mean difference 11.8 msec, P = .046).

Conclusions:

  • Resting cardiac dyssynchrony in ischemic left ventricular dysfunction appears unaffected by dobutamine stress.
  • Revascularization does not significantly alter resting dyssynchrony indices in this patient cohort.
Abstract

More Related Videos

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery09:12

Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery

Published on: March 27, 2018

Related Concept Videos

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...