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Updated: Jul 8, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Pulmonary and cutaneous sarcoidosis associated with interferon therapy for melanoma
Fabien Pelletier1, Philippe Manzoni, Pascale Jacoulet
1Department of Dermatology, Centre Hospitalier Universitaire de Besançon, l'Université de Franche-Comté, France. fabien.pelletier@univ-fcomte.fr
Abstract:
Interferon alfa is widely used as adjuvant therapy for melanoma. Numerous side effects have been attributed to interferon alfa. Interferon alfa-induced sarcoidosis is an uncommon event. We report the third case of pulmonary and cutaneous sarcoidosis in the course of interferon alfa treatment for melanoma. Most cases of sarcoidosis have been reported during treatment of chronic hepatitis C. The prognosis is good with discontinuation of treatment. Other than interferon therapy, sarcoidosis or granulomatosis reactions rarely have been reported in malignant melanoma. We discuss and review the literature on the physiopathology of sarcoidosis brought on by interferon therapy.
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