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Related Concept Videos

Overview of DNA Repair02:25

Overview of DNA Repair

In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
Chemically...
Overview of DNA Repair02:25

Overview of DNA Repair

In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
Chemically...
DNA Damage can Stall the Cell Cycle02:36

DNA Damage can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
DNA Damage Can Stall the Cell Cycle02:36

DNA Damage Can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
Nucleotide Excision Repair01:38

Nucleotide Excision Repair

DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
Nucleotide Excision Repair01:08

Nucleotide Excision Repair

Overview

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Related Experiment Video

Updated: Jul 8, 2026

Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage
10:59

Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage

Published on: August 21, 2021

Age to survive: DNA damage and aging.

Björn Schumacher1, George A Garinis, Jan H J Hoeijmakers

  • 1MGC Department of Cell Biology and Genetics, Center for Biomedical Genetics, Erasmus Medical Center, 3000 DR Rotterdam, The Netherlands.

Trends in Genetics : TIG
|January 15, 2008
PubMed
Summary

DNA damage accumulation is linked to organismal aging and cancer. A conserved

Area of Science:

  • Molecular Biology
  • Genetics
  • Gerontology

Background:

  • Aging is a universal biological process characterized by functional decline and increased mortality.
  • Accumulating DNA damage is a hallmark of aging and a risk factor for age-related diseases.
  • Genetic pathways regulating longevity are interconnected with DNA damage response and repair mechanisms.

Purpose of the Study:

  • To explore the link between DNA damage and organismal aging.
  • To discuss the concept of a conserved 'survival' response to stress.
  • To elucidate how this response impacts cancer and healthy aging.

Main Methods:

  • Review of studies on human progeroid diseases.
  • Analysis of data from mouse models with deficient DNA repair pathways.

More Related Videos

Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model
08:46

Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model

Published on: September 29, 2011

Related Experiment Videos

Last Updated: Jul 8, 2026

Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage
10:59

Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage

Published on: August 21, 2021

Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model
08:46

Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model

Published on: September 29, 2011

  • Conceptual synthesis of evolutionary and molecular findings.

    • Main Results:

    • Longevity-regulating pathways are sensitive to DNA damage and stress.
    • These pathways modulate the rate of DNA damage accumulation and its consequences.
    • A conserved 'survival' response shifts resources from growth to maintenance under stress.

    Conclusions:

    • DNA damage is a critical factor influencing aging and cancer.
    • The 'survival' response is an adaptive mechanism promoting longevity and healthspan.
    • Understanding this response offers insights into mitigating age-related diseases and promoting healthy aging.