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Updated: Jul 8, 2026

Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale
Published on: July 8, 2025
[Trimetazidine-induced encephalopathy with choreiform disorders: a case report]
J Sivet1, B de la Gastine, B Mosquet
1Centre régional de pharmacovigilance de Caen Basse-Normandie, CHRU Côte de Nacre, 14033 Caen cedex, France.
Abstract:
Trimetazidine is known to induce parkinsonism but choreiform disorders have not yet been described with this drug. A 88-year-old patient treated with trimetazidine developed choreiform movements, gait disorders, tremor and visual hallucinations. These symptoms disappeared after drug withdrawal. Although this drug contains a piperazinic ring like other anti-dopaminergic drugs which are already known to potentially induce chorea like neuroleptics and some anti-convulsive drugs. When a patient treated with trimetazidine develops or worsens motor disorders (parkinsonism or choreiform disorders), this drug must be stopped.
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