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Updated: Jul 8, 2026

Examination of Oral Candida Infection in Primary Sjögren's Syndrome Patients
Published on: March 1, 2024
[Melkersson-Rosenthal syndrome treated with clofazimine]
Anette Bygum1, Marie Toft-Petersen
1Dermato-venerologisk Afdeling I, Odense Universitetshospital, DK-5000 Odense C. anette.bygum@ouh.fyns-amt.dk.
Abstract:
Melkersson-Rosenthal syndrome (MRS) is a triad of facial palsy, lingua plicata and chronic orofacial swelling. Mono- and oligosymptomatic forms are common and cheilitis granulomatosa is often considered a monosymptomatic form of MRS. In advanced stages the histological findings are noncaseating granulomas. The etiology remains unclear and treatment is difficult. A few uncontrolled studies have shown corticosteroids and clofazimine to be effective. We report on a 31 year-old man with complete MRS who responded well to treatment with clofazimine.
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