Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Therapeutic safety implications of SARM1 active site inhibitors: subinhibitory concentrations cause neurodegeneration.

npj drug discovery·2026
Same author

Updated 2026 Comprehensive Evidence-Based Guidelines for Facet Joint Interventions in the Management of Chronic Spinal Pain: American Society of Interventional Pain Physicians (ASIPP) Guidelines.

Pain physician·2026
Same author

Safety and efficacy of intradiscal nucleus pulposus allograft versus sham for lumbar discogenic pain associated with degenerative disc disease: study protocol for a randomized clinical trial.

Trials·2026
Same author

Two-Year Outcomes Following Treatment of Painful Lumbar Degenerative Disc Disease with a Percutaneous Polymer-Based Hydrogel Intradiscal Augmentation Implant.

Spine·2026
Same author

Minimally Invasive Sacroiliac Joint Fusion Using 3D Printed Implants and a Lateral Approach: Safety and Effectiveness Assessments of Fusion Performed by Interventional Physicians in a Prospective Multicenter Single-Arm Clinical Study (The FICS Study).

Pain physician·2026
Same author

Feasibility and Safety of Treatment of Painful Lumbar Degenerative Disc Disease with an Injectable Hydrogel Implant at One-year Follow-up.

Pain physician·2026
Same journal

Head-to-head comparison of [<sup>18</sup>F]-mFBG versus [<sup>123</sup>I]-MIBG in neuroblastoma: a systematic review and meta-analysis.

Pediatric radiology·2026
Same journal

Comment on "super-resolution MRI-derived brainstem and cerebellar volumes in fetuses between 22 weeks and 32 weeks of gestation".

Pediatric radiology·2026
Same journal

Ferumoxytol dose optimization for three-dimensional whole-heart magnetic resonance imaging in patients with congenital heart disease.

Pediatric radiology·2026
Same journal

Widely available, general-purpose generative AI applications for radiology education: determining the teaching quality of synthetic pediatric neuroradiology images.

Pediatric radiology·2026
Same journal

Sustainability: a physician's cautionary tale.

Pediatric radiology·2026
Same journal

The invisible footprint: why planetary health is a pediatric radiologist's obligation.

Pediatric radiology·2026
See all related articles

Related Experiment Video

Updated: Jul 8, 2026

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
09:25

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

Pediatric extraskeletal osteosarcoma.

Douglas P Beall1, Justin Ly, Jayson P Bell

  • 1Clinical Radiology of Oklahoma, PO Box 2814, Edmond, OK 73083, USA.

Pediatric Radiology
|January 25, 2008
PubMed
Summary
This summary is machine-generated.

Extraskeletal osteosarcoma (ESOS) is a rare soft-tissue tumor. This case report details a rare instance of ESOS in a 13-year-old girl, highlighting its unusual presentation in young patients.

More Related Videos

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
08:07

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

Establishment of Patient-Derived Xenograft Mouse Model with Human Osteosarcoma Tissues
02:35

Establishment of Patient-Derived Xenograft Mouse Model with Human Osteosarcoma Tissues

Published on: March 22, 2024

Related Experiment Videos

Last Updated: Jul 8, 2026

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
09:25

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
08:07

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

Establishment of Patient-Derived Xenograft Mouse Model with Human Osteosarcoma Tissues
02:35

Establishment of Patient-Derived Xenograft Mouse Model with Human Osteosarcoma Tissues

Published on: March 22, 2024

Area of Science:

  • Oncology
  • Pathology

Background:

  • Extraskeletal osteosarcoma (ESOS) is a rare malignant mesenchymal tumor, constituting ~1% of soft-tissue sarcomas and ~4% of all osteosarcomas.
  • While primary osseous osteosarcomas are common in younger populations, ESOS is infrequently reported in individuals under 40.

Observation:

  • This report focuses on a 13-year-old female patient presenting with a gradually enlarging, painless mass in her left thigh.
  • The observation highlights a rare occurrence of ESOS in a pediatric patient, an age group typically associated with primary bone osteosarcomas.

Findings:

  • Histopathological analysis of ESOS is characterized by the production of osteoid matrix and bone by malignant osteoblasts.
  • The tumor's location in soft tissue, outside the skeletal anatomy, is a defining feature of extraskeletal variants.

Implications:

  • This case underscores the importance of considering rare diagnoses like ESOS in pediatric patients with soft-tissue masses.
  • Further research into the specific characteristics and treatment of pediatric ESOS is warranted to improve patient outcomes.