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Availability of cardio-ankle vascular index (CAVI) as a screening tool for atherosclerosis

Koichiro Kadota1, Noboru Takamura, Kiyoshi Aoyagi

  • 1Department of General Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan.

Circulation Journal : Official Journal of the Japanese Circulation Society
|January 26, 2008
PubMed

Insights

The cardio-ankle vascular index (CAVI) effectively screens for atherosclerosis by correlating with age, blood pressure, and common atherosclerosis markers. Further research is needed to develop a convenient screening system using CAVI.

Area of Science:

  • Cardiovascular Medicine
  • Vascular Biology
  • Biomarkers

Background:

  • A novel index, the cardio-ankle vascular index (CAVI), measures arterial stiffness.
  • CAVI reflects the elasticity of the aorta, femoral artery, and tibial artery.

Purpose of the Study:

  • To clarify the correlation between CAVI and existing atherosclerosis markers.
  • To evaluate CAVI as a potential screening tool for atherosclerosis.

Main Methods:

  • Screened 1,014 Japanese adults from the general population.
  • Measured CAVI, carotid intima-media thickness (CIMT), and homocysteine (HCY).
  • Analyzed correlations between CAVI, age, blood pressure, cholesterol, HbA1c, HCY, and CIMT.

Main Results:

  • CAVI showed a strong association with age in both sexes.
  • Adjusted for age and sex, CAVI correlated with systolic and diastolic blood pressures.
  • CAVI was significantly correlated with total cholesterol, HbA1c, total HCY, and CIMT.

Conclusions:

  • CAVI is an appropriate screening tool for atherosclerosis.
  • Further studies are required to establish a convenient and effective screening system using CAVI.
Abstract

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