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Association between exhaled nitric oxide and systemic inflammatory markers.

Tim J T Sutherland¹, D Robin Taylor, Malcolm R Sears

¹Dunedin Multidisciplinary Health and Development Unit, Department of Preventive and Social Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology

|January 29, 2008

Summary

This study found no link between airway inflammation, measured by exhaled nitric oxide, and systemic inflammation markers like C-reactive protein (CRP) or fibrinogen in young adults.

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Area of Science:

Pulmonary Medicine
Immunology
Epidemiology

Background:

Asthma involves airway inflammation, potentially linked to systemic inflammation.
C-reactive protein (CRP) and fibrinogen are markers of systemic inflammation.
Exhaled nitric oxide (FeNO) is a noninvasive indicator of airway inflammation.

Purpose of the Study:

To investigate the association between FeNO and systemic inflammatory markers (CRP, fibrinogen).

Main Methods:

Utilized data from the Dunedin Multidisciplinary Health and Development Study, a birth cohort.
Assessed 1,000 individuals at age 32 for asthma, atopy, smoking, BMI, FeNO, CRP, and fibrinogen.
Employed statistical analyses to determine correlations between FeNO and systemic markers.

Main Results:

No significant association was observed between FeNO and CRP.
A non-significant trend towards an inverse association between FeNO and fibrinogen was noted.
Adjustments for smoking, corticosteroid use, BMI, and atopy did not yield significant results.

Conclusions:

No association was found between airway inflammation (FeNO) and systemic inflammation (CRP, fibrinogen) in this young adult population.
Findings suggest FeNO may not reflect systemic inflammatory processes in this context.