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Related Concept Videos

Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
Atherosclerosis IV: Nursing Management01:23

Atherosclerosis IV: Nursing Management

Nursing management for a patient with arteriosclerosis involves a comprehensive approach focusing on lifestyle modification, disease monitoring, education, and symptomatic care. Here is an overview of effective nursing strategies:Assessment and Monitoring: Initial and ongoing assessments are crucial. Nurses must document the patient's medical history, including any hypertension, diabetes, hyperlipidemia, and other cardiovascular diseases. Assessments also cover family history and lifestyle...
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...

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Related Experiment Video

Updated: Jul 7, 2026

Quantification of Atherosclerosis in Mice
06:59

Quantification of Atherosclerosis in Mice

Published on: June 12, 2019

Atherosclerosis in Behçet's Syndrome.

Emire Seyahi1, Serdal Ugurlu, Rana Cumali

  • 1Division of Rheumatology, Department of Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey.

Seminars in Arthritis and Rheumatism
|January 29, 2008
PubMed
Summary

Atherosclerosis is not significantly increased in Behçet

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Area of Science:

  • Vascular Medicine
  • Rheumatology
  • Cardiology

Background:

  • Behçet's syndrome (BS) is a multisystem inflammatory disease.
  • Preliminary evidence suggested atherosclerosis may not be elevated in BS.
  • This study aimed to investigate subclinical atherosclerosis in BS patients.

Purpose of the Study:

  • To evaluate the presence of subclinical atherosclerosis in a large cohort of Behçet's syndrome patients.
  • To compare atherosclerosis markers between BS patients with different disease manifestations and control groups.
  • To assess the impact of major organ involvement on atherosclerosis in BS.

Main Methods:

  • A cross-sectional study involving 239 Behçet's syndrome patients, 100 rheumatoid arthritis patients, 74 ankylosing spondylitis patients, and 156 healthy controls.
  • B-mode ultrasonography was used to measure carotid and femoral artery intima-media thickness (IMT) and plaque frequency.
  • Traditional atherosclerotic risk factors were assessed, and analyses were conducted separately for men and women.

Main Results:

  • No significant differences in carotid and femoral artery plaque frequency or IMT were observed between Behçet's syndrome patients, ankylosing spondylitis patients, and healthy controls.
  • Subgroup analysis of BS patients (mucocutaneous/joint disease vs. major organ involvement) showed similar atherosclerosis markers.
  • Only men with rheumatoid arthritis exhibited a significantly higher frequency of carotid artery plaques after adjusting for risk factors.

Conclusions:

  • Elevated atherosclerosis is not a prominent characteristic of Behçet's syndrome, even in patients with major organ involvement.
  • The findings suggest that BS itself does not confer a substantially increased risk for atherosclerosis.
  • Further research may explore specific inflammatory pathways in BS and their relationship with vascular health.