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Related Experiment Video

Updated: Jul 7, 2026

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Prolactin expression in the sheep brain.

Charles E Roselli¹, Sven Bocklandt, Henry L Stadelman

¹Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oreg. 97201-3098, USA. rosellic@ohsu.edu

Neuroendocrinology

|January 29, 2008

Summary

This summary is machine-generated.

Prolactin is found in the sheep brain, including during fetal development. This brain prolactin may influence neuroendocrine stress responses and neurodevelopment.

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Area of Science:

Neuroendocrinology
Developmental Neuroscience
Sheep Models

Background:

Emerging evidence suggests brain-synthesized prolactin plays a role in neuroendocrine regulation, alongside circulating prolactin.
The precise localization and developmental expression patterns of prolactin within the brain remain incompletely understood.

Purpose of the Study:

To investigate the regional expression patterns of prolactin in the adult and developing sheep brain.
To test the hypothesis that prolactin is expressed in key brain regions involved in neuroendocrine homeostasis and behavior.

Main Methods:

Western blot analysis to detect prolactin protein expression.
Reverse transcription-polymerase chain reaction (RT-PCR) to detect and sequence prolactin mRNA.
In situ hybridization histochemistry to visualize the neuroanatomical distribution of prolactin mRNA.

Main Results:

Prolactin mRNA was detected in specific brain regions including the medial preoptic area, periventricular preoptic nucleus, bed nucleus of the stria terminalis, and paraventricular nucleus of the hypothalamus.
Prolactin expression was observed in fetal sheep brains as early as day 60 of gestation, increasing with age and peaking near term.
While no sex difference was noted in the preoptic area, female fetuses exhibited higher amygdalar prolactin mRNA levels at day 100 of gestation.

Conclusions:

Prolactin is expressed in both adult and fetal sheep brains, suggesting a potential role in neurodevelopment.
Brain prolactin may modulate the neuroendocrine stress axis, though further research is needed to elucidate its specific functions.