Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Hypertension I: Introduction01:28

Hypertension I: Introduction

Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
Heart Failure I: Introduction01:27

Heart Failure I: Introduction

Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association of Post-Traumatic Stress Disorder Symptoms Following Hurricane Katrina With Incident Cardiovascular Disease Events Among Older Adults With Hypertension.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry·2018
Same author

Effects of Tobacco on Health and Disease: Three Decades of the Alton Ochsner Award.

Ochsner journal·2017
Same author

Evolution of American Academic Medicine: A View of Its Contributions to World Medicine and Reflections Influenced by Personal Role Models.

Current problems in cardiology·2017
Same author

Walmor C. De Mello: "Your Heart Is Still With Us".

Hypertension (Dallas, Tex. : 1979)·2017
Same author

Review: Promise of prevention and reversal of target organ involvement in hypertension.

Journal of the renin-angiotensin-aldosterone system : JRAAS·2017
Same author

Hypertension: New and Future Challenges.

The Medical clinics of North America·2016

Related Experiment Video

Updated: Jul 7, 2026

A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats
07:31

A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats

Published on: December 2, 2016

The aging hypertensive heart: a brief update.

Dinko Susic1, Edward D Frohlich

  • 1Division of Research, Ochsner Clinic Foundation, New Orleans, LA 70121, USA. dsusic@ochsner.org

Nature Clinical Practice. Cardiovascular Medicine
|January 29, 2008
PubMed
Summary

Aging and hypertension are key risks for cardiovascular disease. Both conditions cause similar heart changes like hypertrophy and dysfunction, increasing morbidity and mortality.

Area of Science:

  • Cardiovascular Medicine
  • Gerontology
  • Hypertension Research

Background:

  • Aging and hypertension are independent, significant risk factors for cardiovascular morbidity and mortality.
  • These conditions share overlapping pathophysiological mechanisms and cardiovascular effects.
  • Understanding their combined impact is crucial for clinical practice.

Purpose of the Study:

  • To summarize the pathophysiology of cardiovascular aging and hypertension.
  • To describe the clinical and therapeutic implications of their combined effects.
  • To highlight shared cardiovascular changes induced by aging and hypertension.

Main Methods:

  • Literature review and synthesis of existing research on cardiovascular aging and hypertension.
  • Analysis of morphologic and functional changes in the cardiovascular system.

Related Experiment Videos

Last Updated: Jul 7, 2026

A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats
07:31

A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats

Published on: December 2, 2016

  • Examination of clinical and therapeutic data related to combined aging and hypertension.

    • Main Results:

    • Cardiovascular aging and hypertension independently contribute to increased cardiovascular risk.
    • Both conditions lead to similar structural and functional heart changes, including left ventricular hypertrophy, fibrosis, and dysfunction.
    • The combined effect exacerbates cardiovascular damage and adverse outcomes.

    Conclusions:

    • Aging and hypertension synergistically worsen cardiovascular health.
    • Therapeutic strategies must consider the dual burden of aging and hypertension.
    • Further research is needed to optimize interventions for this patient population.