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Elevated plasma MMP1 and MMP9 are associated with abdominal aortic aneurysm rupture

W R W Wilson1, M Anderton, E C Choke

  • 1Department of Surgery, University of Leicester, United Kingdom.

European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery
|January 30, 2008
PubMed
Abstract

Insights

Matrix metalloproteinases (MMPs) are linked to abdominal aortic aneurysm (AAA) formation. Elevated MMP9 levels in ruptured AAA patients correlate with increased 30-day mortality, suggesting it as a survival indicator.

Area of Science:

  • Vascular Biology
  • Biomarkers
  • Aneurysm Pathogenesis

Background:

  • Matrix metalloproteinases (MMPs) are implicated in abdominal aortic aneurysm (AAA) development.
  • Circulating MMP levels during AAA rupture remain under-investigated.
  • Understanding these changes is crucial for predicting AAA rupture outcomes.

Purpose of the Study:

  • To quantify plasma levels of MMPs and their inhibitors (TIMPs) in patients with non-ruptured and ruptured AAA.
  • To investigate the association between MMP levels and AAA rupture.
  • To identify potential biomarkers for AAA rupture prognosis.

Main Methods:

  • Pre-operative plasma samples from AAA patients were analyzed using ELISA.
  • Concentrations of various MMPs and TIMPs were measured.
  • Comparison of MMP and TIMP levels between ruptured and non-ruptured AAA groups.

Main Results:

  • Plasma levels of MMP1 and MMP9 were significantly higher in ruptured AAA patients compared to non-ruptured AAA patients.
  • A four-fold increase in pre-operative plasma MMP9 was associated with 30-day non-survival after rupture surgery.
  • MMP9 elevation may indicate a poorer prognosis in ruptured AAA.

Conclusions:

  • These findings reinforce the role of MMPs in the pathogenesis of AAA.
  • Elevated MMP9 levels in ruptured AAA are linked to increased 30-day mortality.
  • MMP9 could serve as a valuable prognostic biomarker for ruptured AAA patients.

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