Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hyperprolactinemia and prolactinomas.

Tatiana Mancini1, Felipe F Casanueva, Andrea Giustina

  • 1Internal Medicine, San Marino Hospital, 47899, Republic of San Marino.

Endocrinology and Metabolism Clinics of North America
|January 30, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of chronic cholecalciferol supplementation and vitamin D status on risk of post-vaccination SARS-CoV-2 breakthrough infection.

Endocrine·2026
Same author

Osteometabolic complications in patients with secreting pituitary adenomas: Is there an impact of gender?

Pituitary·2026
Same author

Current application and future directions for the sarcopenic obesity Global Leadership Initiative (SOGLI) diagnostic algorithm.

Clinical nutrition (Edinburgh, Scotland)·2026
Same author

Neuroendocrine and neural control of bone mass in health and disease.

The Journal of clinical investigation·2026
Same author

Consensus on acromegaly complications: an update.

Pituitary·2026
Same author

Acromegaly complications: an update.

The Journal of clinical endocrinology and metabolism·2026
Same journal

Navigating Adrenal Disease: A Comprehensive, Practical Guide for the Clinician.

Endocrinology and metabolism clinics of North America·2026
Same journal

Adrenal Disorders in Pregnancy.

Endocrinology and metabolism clinics of North America·2026
Same journal

Diagnosis and Management of Adrenocortical Carcinoma.

Endocrinology and metabolism clinics of North America·2026
Same journal

Pheochromocytomas and Paragangliomas.

Endocrinology and metabolism clinics of North America·2026
Same journal

Hereditary Conditions Associated with Adrenocortical Carcinoma, Pheochromocytoma, and Other Adrenal Tumors: Genetic Testing and Management Recommendations.

Endocrinology and metabolism clinics of North America·2026
Same journal

Primary Bilateral Macronodular Adrenal Hyperplasia.

Endocrinology and metabolism clinics of North America·2026
See all related articles

Hyperprolactinemia, elevated prolactin levels, can stem from various factors affecting dopamine. Prolactinomas are the most common cause, often leading to hypogonadism, but are treatable with medical or surgical therapies.

Area of Science:

  • Endocrinology
  • Neuroendocrinology

Background:

  • Prolactin secretion is tightly regulated by dopamine.
  • Disruptions in dopamine pathways can lead to hyperprolactinemia.
  • Hyperprolactinemia has widespread clinical effects beyond the reproductive axis.

Purpose of the Study:

  • To review the causes and clinical implications of hyperprolactinemia.
  • To highlight prolactinomas as the most frequent cause of hyperprolactinemia after excluding drug effects.
  • To discuss the management and outcomes of hyperprolactinemia.

Main Methods:

  • Literature review on prolactin regulation and hyperprolactinemia.
  • Analysis of clinical presentation and common etiologies.
  • Overview of therapeutic approaches for prolactinomas.

Related Experiment Videos

Main Results:

  • Hyperprolactinemia results from impaired dopamine synthesis, transport, or receptor action.
  • Prolactinomas are the leading cause of hyperprolactinemia in the absence of drug induction.
  • Hypogonadism is the most prevalent symptom in both sexes.
  • Medical and surgical treatments offer favorable outcomes for prolactinomas.

Conclusions:

  • Hyperprolactinemia is a complex endocrine disorder with diverse etiologies.
  • Prompt diagnosis and management of prolactinomas are crucial for patient outcomes.
  • Effective treatments can lead to control or cure of prolactinomas and resolution of symptoms.