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04:45
Real-Time Electrocardiogram Monitoring During Treadmill Training in Mice
Published on: May 5, 2022
Ventricular arrhythmias during clinical treadmill testing and prognosis
Frederick E Dewey1, John R Kapoor, Ryan S Williams
1Stanford University Medical School, Palo Alto, California, USA. rdewey@stanford.edu
Archives of Internal Medicine
|January 30, 2008
Summary
Recovery premature ventricular complexes (PVCs) during exercise testing predict increased mortality in heart failure-free individuals, highlighting their prognostic value.
Area of Science:
- Cardiology
- Exercise Physiology
- Clinical Research
Background:
- Exercise-associated ventricular arrhythmias are common but their prognostic significance is unclear.
- Premature ventricular complexes (PVCs) during and after exercise testing warrant further investigation.
Purpose of the Study:
- To evaluate the clinical correlates of exercise and recovery PVCs.
- To determine the prognostic significance of exercise-associated PVCs in heart failure-free patients.
Main Methods:
- 1847 heart failure-free patients underwent treadmill testing.
- Logistic regression analyzed clinical and exercise test associations.
- Propensity score-adjusted Cox survival analyses assessed prognostic significance.
Main Results:
- 46% developed exercise PVCs; 33.6% had recovery PVCs.
- Recovery PVCs, unlike exercise PVCs, were linked to coronary disease and ST-segment depression.
- Recovery PVCs significantly increased mortality risk (HR 1.71-1.96) and reclassified risk in Duke Treadmill Scores.
Conclusions:
- Recovery PVCs are associated with increased mortality in a heart failure-free population.
- Recovery PVCs augment established cardiovascular risk markers.
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