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Updated: Jul 7, 2026
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Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis
Published on: July 4, 2007
Limited chronic focal encephalitis: another variant of Rasmussen syndrome?
A Gambardella1, F Andermann, S Shorvon
1Institute of Neurology, University Magna Graecia, Catanzaro Viale Europa, Località Germaneto, 88100 Catanzaro, Italy. a.gambardella@isn.cnr.it
Neurology
|January 30, 2008
Summary
This study identifies a milder, nonprogressive variant of Rasmussen encephalitis (RE), a rare neurological disorder. Findings suggest RE may present with less severe symptoms than previously understood.
Area of Science:
- Neurology
- Neuroimmunology
- Neuroinflammation
Background:
- Rasmussen encephalitis (RE) is a rare, severe autoimmune disease affecting one brain hemisphere.
- Characterized by progressive neurological decline, including seizures and motor deficits.
Observation:
- Three adult female patients presented with chronic focal encephalitis.
- Clinical presentation included partial seizures and choreo-dystonic movements, with minimal focal motor deficits.
Findings:
- Histological examination and MRI confirmed Rasmussen encephalitis.
- The observed cases exhibited a less aggressive, nonprogressive disease course.
Implications:
- These findings expand the known spectrum of Rasmussen encephalitis phenotypes.
- Suggests the existence of milder, nonprogressive forms of RE, challenging previous notions of its severity.
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