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[Protective effect of NEP on Abeta-induced apoptosis in PC12 cells]
Ji-Ping Zeng1, Ling-Ling Yang, Wei-Fang Wu
1Biochemistry and Molecular Biology Department, School of Medicine, Shandong University, Jinan, 250012, China.
Objective:
To identify the effect of NEP on Abeta -induced apoptosis in PC12 cells.
Methods:
PC12 cells that stably express NEP is generated and the effect of NEP on the process of apoptosis induced by Abeta is analyzed, including the viability of the cells, the production of LDH, ROS and ATP, the activity of Caspase-3.
Results:
NEP could improve the viability of cells and the production of ATP, inhibit the release of LDH and ROS. In the same time, the activity of caspase-3 descended (P < 0.05). But iNEP had not significant effect on cells apoptosis (P > 0.05).
Conclusion:
NEP has the protective effect on Abeta-induced apoptosis in PC12 cells.
