Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Population-based pilot screening programme for abdominal aortic aneurysm in the Czech Republic.

Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti·2025
Same author

Olfactory implants: international opinion paper on emerging technologies and clinical applications.

Rhinology·2025
Same author

The collaborative working group method for pre-trial knowledge mobilisation: a qualitative evaluation of a structured process for iteratively refining a complex intervention (DAFNEplus).

Pilot and feasibility studies·2024
Same author

Can MRI predict olfactory loss and improvement in posttraumatic olfactory dysfunction?

Rhinology·2023
Same author

Systematic review and meta-analysis of randomized controlled trials of psychological interventions to improve glycaemic control in children and adults with type 1 diabetes.

Diabetic medicine : a journal of the British Diabetic Association·2020
Same author

Working with Insulin, Carbohydrates, Ketones and Exercise to Manage Diabetes (WICKED): evaluation of a self-management course for young people with Type 1 diabetes.

Diabetic medicine : a journal of the British Diabetic Association·2019
Same journal

[Preparation for the medical specialist examination : Part 81].

HNO·2026
Same journal

[Otorhinolaryngologic infections in the post-pandemic context: What can we learn from the literature?]

HNO·2026
Same journal

[The digits-in-noise test in audiological cochlear implant aftercare].

HNO·2026
Same journal

[Complications of acute otitis media].

HNO·2026
Same journal

HNO·2026
Same journal

[Facial fillers: evidence base, anatomical principles, materials, risks, techniques, and future perspectives].

HNO·2026
See all related articles

Related Experiment Video

Updated: Jul 7, 2026

Posterior Semicircular Canal Approach for Inner Ear Gene Delivery in Neonatal Mouse
03:52

Posterior Semicircular Canal Approach for Inner Ear Gene Delivery in Neonatal Mouse

Published on: March 2, 2018

[Stem-cell-based approaches for treating inner ear diseases].

P Senn1, S Heller

  • 1Universitätsklinik für Hals- Nasen- und Ohrenheilkunde, Kopf- und Halschirurgie, Inselspital, 3010, Bern, Schweiz. pascal.senn@insel.ch

HNO
|January 31, 2008
PubMed
Summary
This summary is machine-generated.

Stem cells show promise for inner ear regeneration, with new studies generating key cell types. However, functional hearing or vestibular restoration has not yet been achieved.

More Related Videos

Initiating Differentiation in Immortalized Multipotent Otic Progenitor Cells
12:17

Initiating Differentiation in Immortalized Multipotent Otic Progenitor Cells

Published on: January 2, 2016

A Protocol for Decellularizing Mouse Cochleae for Inner Ear Tissue Engineering
09:53

A Protocol for Decellularizing Mouse Cochleae for Inner Ear Tissue Engineering

Published on: January 1, 2018

Related Experiment Videos

Last Updated: Jul 7, 2026

Posterior Semicircular Canal Approach for Inner Ear Gene Delivery in Neonatal Mouse
03:52

Posterior Semicircular Canal Approach for Inner Ear Gene Delivery in Neonatal Mouse

Published on: March 2, 2018

Initiating Differentiation in Immortalized Multipotent Otic Progenitor Cells
12:17

Initiating Differentiation in Immortalized Multipotent Otic Progenitor Cells

Published on: January 2, 2016

A Protocol for Decellularizing Mouse Cochleae for Inner Ear Tissue Engineering
09:53

A Protocol for Decellularizing Mouse Cochleae for Inner Ear Tissue Engineering

Published on: January 1, 2018

Area of Science:

  • Regenerative Medicine
  • Otolaryngology
  • Stem Cell Biology

Context:

  • Stem cell therapy is established for hematologic cancers but not widely applied for other conditions.
  • Inner ear disease treatments remain limited, lacking regenerative options.
  • Recent advancements focus on generating inner ear cell types from stem cells.

Purpose:

  • To review the current state of stem cell-based inner ear regeneration.
  • To highlight the generation of specific inner ear cell types from stem cells.
  • To identify the gap in functional restoration for hearing and vestibular disorders.

Summary:

  • Physicians recognize stem cells' regenerative potential for tissue repair.
  • Studies report successful generation of inner ear cells (hair cells, supporting cells, spiral ganglion neurons) from stem cells.
  • These studies, while morphologically and immunologically distinct, lack data on functional hearing or vestibular recovery.

Impact:

  • Highlights the potential of stem cells for treating inner ear diseases.
  • Identifies the critical need for functional validation in stem cell therapies for the inner ear.
  • Guides future research towards achieving hearing restoration and vestibular function recovery.