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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Predictors of migraine headache recurrence: a pooled analysis from the eletriptan database.

David W Dodick¹, Richard B Lipton, Peter J Goadsby

¹Department of Neurology, Mayo Clinic, Scottsdale, AZ 85259, USA.

|February 1, 2008

Summary

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Female gender, older age, and severe pain predict migraine recurrence. Eletriptan effectively reduces headache recurrence in high-risk migraine patients.

Area of Science:

Neurology
Clinical Pharmacology

Background:

Migraine recurrence after initial treatment is common.
Identifying predictors of recurrence is crucial for effective migraine management.

Purpose of the Study:

To identify clinical variables predicting headache recurrence within 22 hours after successful acute migraine treatment.
To evaluate eletriptan's efficacy in reducing recurrence in high-risk patient groups.

Main Methods:

Pooled data from 10 randomized, double-blind, placebo-controlled trials of eletriptan and sumatriptan.
Multivariable logistic regression identified predictors of recurrence.
Treatment response analyzed in subgroups with identified risk factors.

Main Results:

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Last Updated: Jul 7, 2026

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29% of patients experienced migraine recurrence after initial response.

Female gender, age ≥ 35 years, and severe baseline pain predicted recurrence.

Eletriptan (40 mg and 80 mg) significantly reduced recurrence in high-risk subgroups compared to placebo.

Conclusions:

Female gender, older age, and severe baseline pain are key predictors of migraine recurrence.
Eletriptan demonstrates effectiveness in mitigating headache recurrence in at-risk migraine populations.