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Updated: Jul 7, 2026

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
Published on: September 20, 2019
Cholestasis induced by total parenteral nutrition
Francesco William Guglielmi1, Nunzia Regano, Silvia Mazzuoli
1Section of Gastroenterology & Artificial Nutrition, Hospital San Nicola Pellegrino, 70059 Trani, Bari, Italy. guglielmifw@libero.it
Total parenteral nutrition (TPN) can cause liver injury, known as TPN-induced cholestasis (TPN-IC). This condition involves rapid liver damage, potentially leading to cirrhosis, and requires careful management for better patient outcomes.
Area of Science:
- Hepatology
- Gastroenterology
- Clinical Nutrition
Background:
- Parenteral nutrition (PN) is crucial for intestinal failure.
- TPN-induced cholestasis (TPN-IC) presents with bile duct regeneration, portal inflammation, and fibrosis.
- TPN-IC can rapidly progress to liver cirrhosis.
Purpose of the Study:
- To define TPN-IC.
- To review incidence, hepatic changes, and histopathology.
- To discuss risk factors, pathogenesis, and clinical implications of TPN-IC.
Main Methods:
- Literature review on TPN-IC.
- Analysis of hepatic changes and histopathologic findings.
- Synthesis of data on risk factors and pathogenesis.
Main Results:
- TPN-IC characterized by specific liver histopathology.
- Identified key risk factors and pathogenic mechanisms.
- Highlighted rapid progression and potential for cirrhosis.
Conclusions:
- Understanding TPN-IC is vital for patient care.
- Improved management strategies can enhance quality of life and prognosis.
- Further research may optimize PN protocols to mitigate liver injury.
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