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Measurement of human cochlear blood flow
J M Miller1, G Bredberg, R Grenman
1Kresge Hearing Research Institute, University of Michigan, Ann Arbor 48109-0506.
The Annals of Otology, Rhinology, and Laryngology
|January 1, 1991
Summary
Directly measuring human cochlear blood flow (CBF) is feasible using laser-Doppler. Findings show carbogen has minimal effect, while electrical stimulation and warm water irrigation increase CBF.
Area of Science:
- Otolaryngology
- Neurosurgery
- Biomedical Engineering
Background:
- Cochlear blood flow (CBF) is crucial for auditory function.
- Direct measurement of human CBF is challenging.
- Laser-Doppler (L-D) flowmetry offers a potential solution.
Purpose of the Study:
- To assess the feasibility of measuring human cochlear blood flow (CBF) using laser-Doppler (L-D) flowmetry.
- To investigate the effects of carbogen breathing, electrical stimulation, and warm water irrigation on human CBF.
Main Methods:
- Laser-Doppler (L-D) flowmetry (Periflux PR2-B) was employed to measure CBF.
- Measurements were taken on the promontory and/or round window membrane in human subjects.
- Stimuli included carbogen breathing, direct electrical cochlear stimulation, and warm water irrigation.
Main Results:
- Carbogen breathing showed minimal impact on CBF in both subject groups.
- Electrical stimulation increased CBF by 15-25% in 7 of 9 anesthetized subjects.
- Warm water irrigation (44-49°C) induced 20-60% CBF increases, partially recoverable.
Conclusions:
- Direct measurement of human cochlear blood flow (CBF) is feasible with L-D flowmetry.
- Carbogen has a negligible effect on human CBF.
- Electrical stimulation and warm water irrigation can increase human CBF.