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[The effect of ischemia-related leukoaraiosis on the conscious disturbance after stroke]

Yan-Nan Fang1, Ai-Wu Zhang, Hua Li

  • 1Department of Neurology, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, China.

Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi
|February 7, 2008
PubMed
Abstract

Insights

Leukoaraiosis, a white matter change, is an independent risk factor for conscious disturbance after acute cerebral infarction. While fewer patients with leukoaraiosis experienced conscious disturbance, their condition was more severe and recovery slower.

Area of Science:

  • Neurology
  • Neuroimaging
  • Cerebrovascular Disease

Context:

  • Acute cerebral infarction affects numerous individuals globally, with conscious disturbance being a significant complication.
  • Leukoaraiosis, characterized by white matter changes around cerebral ventricles, is increasingly recognized as a potential contributor to stroke outcomes.

Purpose:

  • To investigate the impact of leukoaraiosis on the development and severity of conscious disturbance in patients following an acute cerebral infarction.
  • To identify independent risk factors for conscious disturbance, including leukoaraiosis and Oxfordshire Community Stroke Project (OCSP) classification.

Summary:

  • A follow-up study of 138 acute cerebral infarction patients revealed leukoaraiosis as an independent risk factor for conscious disturbance (OR = 5.294).
  • Patients with leukoaraiosis showed lower Glasgow Coma Scale scores at initial, 1-month, and 3-month follow-ups compared to controls.
  • While leukoaraiosis was associated with a lower incidence of conscious disturbance, its severity was greater and recovery slower, suggesting a complex, potentially protective yet exacerbating role.

Impact:

  • Findings highlight leukoaraiosis as a crucial factor influencing post-stroke conscious disturbance, necessitating consideration in clinical assessment and management.
  • The study underscores the dual role of leukoaraiosis, potentially conferring some resilience to chronic ischemia while worsening acute outcomes.
  • Results emphasize the importance of integrating neuroimaging findings like leukoaraiosis with clinical classifications (OCSP) for comprehensive stroke patient evaluation.

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