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Related Experiment Video

Updated: Jul 7, 2026

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas
05:31

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas

Published on: January 26, 2024

Maternal periodontitis as a potential risk variable for preeclampsia: a case-control study.

Fernanda Mafra Siqueira1, Luís Otávio Miranda Cota, José Eustáquio Costa

  • 1Department of Periodontology, Faculty of Dentistry, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.

Journal of Periodontology
|February 7, 2008
PubMed
Summary

Maternal periodontitis, defined by gum disease indicators like bleeding on probing, is a significant risk factor for preeclampsia. This study highlights the need for prenatal periodontal care to potentially reduce preeclampsia incidence.

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Last Updated: Jul 7, 2026

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas
05:31

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas

Published on: January 26, 2024

Area of Science:

  • Obstetrics and Gynecology
  • Periodontology
  • Public Health

Background:

  • Conflicting evidence exists regarding the association between maternal periodontitis and preeclampsia risk.
  • This study aimed to clarify this relationship and assess the impact of periodontal disease severity.

Purpose of the Study:

  • To evaluate the association between maternal periodontitis and preeclampsia, considering confounding factors and interactions.
  • To determine the influence of periodontal parameters (bleeding on probing, probing depth, clinical attachment loss) on preeclampsia risk.

Main Methods:

  • A case-control study involving 1,206 Brazilian women, with 164 preeclamptic and 1,042 controls.
  • Maternal periodontitis was defined by probing depth (PD) and clinical attachment loss (CAL) criteria. Matching and multivariate analyses were employed.

Main Results:

  • Maternal periodontitis remained significantly associated with preeclampsia after controlling for confounders (OR=1.94) and after matching (OR=1.52).
  • Increased odds of preeclampsia correlated with a higher number of sites exhibiting bleeding on probing (BOP), PD, and CAL exceeding specific thresholds.

Conclusions:

  • Maternal periodontitis is confirmed as a risk factor for preeclampsia.
  • Integrating periodontal care into prenatal programs is crucial for potentially mitigating preeclampsia risks.